SCN8A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: Similarly, various forms of epilepsy, such as temporal lobe epilepsy, SCN8A epileptic encephalopathy, and Dravet syndrome, are associated with an imbalanced E-I ratio arising from dysfunction in SST and PV interneurons (Tai et al., 2014; Wengert et al., 2021; Drexel et al., 2022).