This meta-analysis confirmed that the GBA variant rate was significantly higher in DLB group than in the control group, as were the variant rates of L444P, N370S, and E326K, whereas the variant rate of T369M showed no significant difference between the groups.The GBA variant group had a younger age of onset and lower MoCA score than the GBA non-variant group in DLB patientsThere were no significant sex differences in GBA variants between sexes. This evidence concerns the gene GBA1 and Lewy body dementia.