SNCA and early-onset autosomal dominant Alzheimer disease: On a pathological level, DLB is characterized by the presence of Lewy bodies (i.e., neuronal inclusions of alpha-synuclein) with differing degrees of co-existing Alzheimer’s disease (AD)-related pathology (i.e., amyloid plaques and neurofibrillary tangles (NFT)) (212, 213).