MAPT and early-onset autosomal dominant Alzheimer disease: Clinical and neuropathological assessments:Males and females were divided into two groups based on the staging of LB and AD pathologiesCDR-Dementia Staging Instrument-Sum of BoxesThal phase (amyloid-B plaque score), Braak tau stage (neurofibrillary tangle stage) and Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) score (neuritic plaque score)