SNCA and multiple system atrophy: The alpha-synucleinopathies, including idiopathic PD, Dementia with Lewy Bodies (DLB), Multiple systems atrophy (MSA), pure autonomic failure and REM sleep behavior disorder (RBD), have been also associated with synaptopathy and inflammation, as of yet poorly understood α-synuclein-related mechanisms, that likely contribute to the initiation and propagation of the disease (3).