Clinical assessments and CSF profile:Demographics and neuropsychological assessments (i.e., MMSE)a1-antichymotrypsin (ACT) concentrations in CSF and the basic CSF AD-biomarker profile (AB1-42, T-Tau, P-Tau181)CSF Orexin samples were determined using radioimmunoassayCSF alphasynuclein was determined using enzyme-linked immunosorbent assay (ELISA). Here, MAPT is linked to Alzheimer disease.