Despite these different patterns of demyelination, MOGAD and AQP4 + NMOSD share some clinical features, such as optic neuritis and longitudinally extensive myelitis (18, 89), and cytokine profiles (upregulation of Th17-related cytokines) in the CSF (62) as autoantibody-associated CNS diseases. Here, AQP4 is linked to optic neuritis.