Fibrosis index 5 (FIB-5), another score for estimating hepatic fibrosis, was studied by Maeda et al. Their research showed that FIB-5, calculated from serum albumin, AST, ALT, alkaline phosphatase (ALP) serum activities and platelet count was superior to FIB-4 at predicting death or hospital readmission for heart failure in patients hospitalized with acute decompensated heart failure, after adjusting for significant clinical factors. The gene discussed is ALB; the disease is heart failure.