The AUC for cTnI was 0.76, however, when cTnI was combined with NT-proBNP, baseline eGFR and white blood cell count in a statistical model, the AUC rose to 0.92, indicating that other biomarkers can supplement and increase the predictive and diagnostic value of cTnI for CRS when combined (57). The gene discussed is TNNI3; the disease is congenital rubella syndrome.