In order to limit HIV related oral disease and to optimize oral healthcare among PLHIV, we evaluated the type and distribution of oral candidiasis with respect to ART-profile including both immunological and virological profiles of PLHIV in two health facilities (Chantal Biya International Reference Centre for Research on HIV/AIDS Prevention and Management (CIRCB) and the Jamot Hospital of Yaoundé); which are respectively among the leading HIV/AIDS monitoring (viral load and CD4 count) and treatment sites in Yaoundé. This evidence concerns the gene CD4 and oral candidiasis.