Our results showed that bacteria genera enriched in the ND and HFD+P groups, such as Lactobacillus, negatively correlated with NAFLD-related metabolic parameters and liver inflammatory factors, such as the levels of serum TC (r = −0.8, p = 0.009), TG (r = −0.85, p = 0.003), AST (r = −0.933, p = 0.0002 < 0.001), ALT (r = −0.692, p = 0.038), HDL-C (r = −0.8 p = 0.009), LDL-C (r = −0.866, p = 0.002), TBA (r = −0.916, p = 0.0005), IL-1β (r = −0.695, p = 0.037), and TNF-α (r = −0.864, p = 0.002). Here, IL1B is linked to metabolic dysfunction-associated steatotic liver disease.