Similarly, membrane bond 20:4n-6 in erythrocytes is known to be non-enzymatically oxidized/peroxidized or metabolized to eicosanoids and endocannabinoids by activity of phospholipases, cyclooxygenase, lipoxygenase, cytochrome P450-dependent enzymes, phosphatases and diacylglycerol-lipase, and their activity can be changed in obesity and MetS, which are considered as pro-inflammatory states (208, 209). Here, LIPA is linked to obesity due to melanocortin 4 receptor deficiency.