SCD and Obesity: Liver-specific knock-out of Scd1 gen protects from the HSD induced adiposity in the same degree as the whole body Scd1 knock-out, but not from the HFD induced adiposity, indicating that in rodents, the liver D9D has a vital role for obesity development particularly in circumstances with high carbohydrate intakes, while in circumstances with high fat intakes, the adipose tissue D9D is more involved (171, 173).