Liver-specific knock-out of Scd1 gen protects from the HSD induced adiposity in the same degree as the whole body Scd1 knock-out, but not from the HFD induced adiposity, indicating that in rodents, the liver D9D has a vital role for obesity development particularly in circumstances with high carbohydrate intakes, while in circumstances with high fat intakes, the adipose tissue D9D is more involved (171, 173). Here, SCD is linked to obesity due to melanocortin 4 receptor deficiency.