Functional analysis showed that DIICs-correlated DEGs were significantly enriched into 26 GO terms (Figure 2B), such as SRP-dependent cotranslational protein targeting to membrane, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, translation, and 8 KEGG pathways (Figure 2C), including ribosome, oxidative phosphorylation, Huntington’s disease, Alzheimer’s disease, Parkinson’s disease, non-alcoholic fatty liver disease (NAFLD), proteasome and cardiac muscle contraction. Here, UCN2 is linked to juvenile Huntington disease.