One of the four unique SNPs that significantly differentiated PCOS+HT and PCOS (padj < 0.05) in TaqMan genotyping was rs4656077 in the GBP3 gene (Table 3), which encodes a guanylate-binding protein belonging to the family of IFN-γ-inducible GTPases involved in host defense against infection and inflammasome response, as well as in metabolic inflammatory diseases and cancer (77). This evidence concerns the gene GBP3 and polycystic ovary syndrome.