INSR and polycystic ovary syndrome: To date, only a few polymorphisms contributing to both PCOS and HT have been proposed, including the most convincingly described polymorphisms in FBN3, CYP1B1, and GNRHR, and GWAS-selected single nucleotide polymorphisms (SNPs) in FSHR and INSR which are common in PCOS and HT (17, 19, 37).