GBP3 and cancer: One of the four unique SNPs that significantly differentiated PCOS+HT and PCOS (padj < 0.05) in TaqMan genotyping was rs4656077 in the GBP3 gene (Table 3), which encodes a guanylate-binding protein belonging to the family of IFN-γ-inducible GTPases involved in host defense against infection and inflammasome response, as well as in metabolic inflammatory diseases and cancer (77).