Recently, two rare missense variants in FBN3 encoding an ECM protein, a member of the fibrillin/latent TGF-β binding protein (LTBP) family, and a missense variant in FN1, which encodes a member of the fibronectin family, were identified by WES in families with PCOS (48). The gene discussed is FN1; the disease is polycystic ovary syndrome.