Fn14 expressing mouse tumor organoids (MTOs) (Supplemental Data Figure S3), derived from tumors originating from Apcko/ko, KrasLSL-G12D, Tgfbr2ko/ko and Trp53ko/ko intestinal stem cells that imitate the microenvironment and severity of human colorectal cancer (18) were expanded in vitro and injected subcutaneously into the flank of syngeneic C57BL/6J recipients. Here, TNFRSF12A is linked to neoplasm.