Human NSCLC CD8+ TRM cells display a particular molecular signature, with the expression of transcription factors specific to resident T cells, including NF-κB, BATF (basic leucine zipper transcription factor), Aiolos and AHR (aryl hydrocarbon receptor), which are probably involved in the maintenance and effector functions of these lymphocytes (17, 18). The gene discussed is CD8A; the disease is non-small cell lung carcinoma.