EGFR and cancer: Notably, in a co-culture of T cells with mCherry-expressing EGFR+ OVCAR-3scFvCD3, treatment with CD27xEGFR increased cancer cell killing by T cells (Figure 4G, ~25% reduction at an E:T ratio of 5:1) whereas with the corresponding EGFRKO cells, treatment with CD27xEGFR had no effect on cancer cell survival when compared to medium control (Figure 4H).