Adipocyte plasma membrane-associated protein (APMAP) is ubiquitously expressed in all cell lines and various types of musculoskeletal disorders (89), APMAP deficiency synergizes with CD47-blocking monoclonal antibodies to enhance phagocytic function, promotes the engulfment of apoptotic cells, suppress antigen presentation-induced autoimmune responses, limit immune-inflammatory damage, and contribute to tissue homeostasis maintenance (144–146). This evidence concerns the gene APMAP and musculoskeletal system disorder.