Studies using mouse models of autoimmune diseases have found that CD47-SIRPα and CD24-SIGLEC10 polymorphisms affect macrophages’ phagocytosis of apoptotic cells, suggesting that modulating the CD24-SIGLEC10 axis may have potential value in various musculoskeletal disorders (87, 88). This evidence concerns the gene CD47 and musculoskeletal system disorder.