While the control group did not achieve 50% inhibition under the maximum concentration of TMZ treatment, the half‐maximal inhibitory concentration (IC50) values of TMZ decreased significantly after knockdown of HMOX1 (IC50 = 510 μM), STEAP3 (IC50 = 588 μM), and LTF (IC50 = 1211 μM) in U87 glioma cells (Figure 8J). The gene discussed is HMOX1; the disease is central nervous system cancer.