In addition to alterations in the TME that impact cell surface receptor expression in mesothelial cells, it has been shown that pyruvate dehydrogenase kinase 1 (PDK1) overexpression in ovarian cancer cells results in increased adhesion to mesothelial cells via α5β1 integrins and secretion of IL-8 (19). The gene discussed is CXCL8; the disease is ovarian cancer.