Specific links between VCP-complexes have been established or predicted for neurodegeneration in general [106–108], amyotrophic lateral sclerosis (ALS [109–111]), Parkinson’s disease (PD [55, 112–115]), Alzheimer’s disease (AD [112, 116–119]), Huntington’s disease (HD [91, 120–122]) and others. Here, VCP is linked to early-onset autosomal dominant Alzheimer disease.