VCP mutations can instigate other neurodegenerative conditions [277], such as amyotrophic lateral sclerosis (ALS [278]), Parkinson’s disease (PD [253, 279]), Charcot-Marie-Tooth disease type 2y (CMT2Y [249, 250, 253]), and hereditary spastic paraplegia (HSP [280]). Here, VCP is linked to hereditary spastic paraplegia.