VCP and Spinocerebellar ataxia type 3: Aside from causing neurodegeneration, VCP variants also modulate the pathologies of Alzheimer’s disease (AD) and some polyglutamine (polyQ) diseases, such as Huntington’s disease (HD) and spinocerebellar ataxia type 3 (SCA3/Machado-Joseph disease) [28, 119, 121].