Recent literature has reported that SYNPO2 stabilizes the LATS2 protein, promoting the phosphorylation of YAP1 at S127 and leading to the retention of YAP and TAZ in the cytoplasm, restraining the TEAD transcription activity and downstream gene expression such as SRY-Box Transcription Factor 2(SOX2), NONAG and POU Class 5 Homeobox 1(POU5F1/OCT4), to inhibit the metastasis of triple-negative breast cancer [45]. The gene discussed is YAP1; the disease is triple-negative breast carcinoma.