MUC1 and breast carcinoma: Several MUC1 aptamers, such as S1.3, S2.2, 5TR1, 5TRG2, and MA3, have been isolated for the diagnosis and therapy of these cancers.227 Chang et al. conjugated the MUC1 aptamer 5TRG2 to doxorubicin-intercalated DNA icosahedra nanoparticles and showed that 5TRG2 mediated specific and efficient internalization of the nanoparticles into MUC1-positive human breast cancer MCF7 cells but not into MUC1-negative CHO-K1 cells.