In a recent study, Lee and colleagues developed a doxorubicin-loaded human serum albumin nanoparticles/chlorin e6-loaded microbubbles complex (DOX-NPs/Ce6-MBs), and showed that ultrasound irradiation not only enhanced the extravasation of DOX-NPs and Ce6-liposomes from tumor blood vessels but also improved the penetration of these drugs into tumor tissues. Here, ALB is linked to neoplasm.