Moreover, a notable decrease in the number of lung metastases in tumor-bearing mice indicated the efficient elimination of CTCs in the bloodstream by the platelet membrane-coated nanovehicle.326 Similarly, TRAIL-functionalized platelet membrane-coated silica particles exhibited excellent antitumor efficacy by neutralizing CTCs and attenuating metastasis in MDA-MB-231 breast cancer xenografts.327. The gene discussed is TNFSF10; the disease is breast cancer.