EpCAM is overexpressed in many cancer cells and it also serves as a marker of cancer stem cells (CSCs).220 It plays important roles in cell adhesion, proliferation, epithelial-to-mesenchymal transition (EMT), tumor invasion and metastasis, as well as stemness of cancer cells.221 These properties make EpCAM an attractive target for cancer treatment. Here, EPCAM is linked to neoplasm.