Some galectins (especially galectin-1 and galectin-3) are overexpressed in a variety of tumors and can promote tumor metastasis by modulating cell adhesion, cell migration, and the immune response.289 Balakrishnan et al., have recently developed a multifunctional core-shell nanoparticle decorated with citrus pectin (CP), which was pre-modified to expose β-galactosides that can be specifically recognized by galectin-3 overexpressed on the surface of MDA-MB-231 breast cancer cells.290. The gene discussed is LGALS3; the disease is neoplasm.