Moreover, a notable decrease in the number of lung metastases in tumor-bearing mice indicated the efficient elimination of CTCs in the bloodstream by the platelet membrane-coated nanovehicle.326 Similarly, TRAIL-functionalized platelet membrane-coated silica particles exhibited excellent antitumor efficacy by neutralizing CTCs and attenuating metastasis in MDA-MB-231 breast cancer xenografts.327. This evidence concerns the gene TNFSF10 and breast carcinoma.