Abnormal expression of PSD95 has been documented in various human disorders affecting both the CNS and PNS, such as Alzheimer’s disease, Huntington’s disease, schizophrenia, autism spectrum disease, and pain.44,45 SYN encodes phosphoproteins that play crucial roles in the regulation of neurotransmission and neurodevelopment.46 The results showed that TLR3 contributed to neuroplasticity changes by reducing dendritic spines in neurons and inhibiting the expression of PSD95 and SYN. This evidence concerns the gene TLR3 and juvenile Huntington disease.