In recent years, studies have also explored the impact of poly (I:C), a synthetic analog of dsRNAs, on the brain’s cytokine responses in aged animals.25 Therefore, we conducted this study to better understand how exRNAs, particularly dsRNAs, which were exposed under chronic neuropathic pain-induced stress conditions and triggered TLR3 in the hippocampus and activated downstream signaling, contributed significantly to the development of chronic neuropathic pain-induced cognitive impairment. This evidence concerns the gene TLR3 and Pain.