The majority of TAMs in glioma are primed into M2‐TAMs, while a small subset adopts the M1‐TAM phenotype.[20, 21] Notably, M1‐TAMs prefer energy metabolism via glycolysis and the pentose phosphate pathway, which activates NADPH oxidase 2 (NOX2) to produce reactive oxygen species (ROS). The gene discussed is CYBB; the disease is central nervous system cancer.