MRC1 and neoplasm: Third, an increased T/B ratio was obtained with a hierarchical targeting strategy.[37] This strategy consists of three stages including (1) passive accumulation in tumor tissue via enhanced permeability and retention (EPR) effect; (2) targeting M2‐TAMs by binding to their membrane receptor CD206; (3) fluorescence activation in the acidic phagosomes of M2‐TAMs after internalization.