In previous studies, YAP1 was reported to maintain human MSCs in a younger state, and overexpression of YAP1 rejuvenated senescent MSCs in a replicative senescence model.[73] An anti‐aging effect of YAP1 was also found in hepatocytes, hepatic stellate cells, and tumor cells.[26, 74, 75] There are studies demonstrating that YAP1 plays an important role in maintaining the function of stem cells.[76] In terms of immune regulation, most studies focused on the role of YAP1 in immune cells and tumor cells. Here, YAP1 is linked to neoplasm.