Furthermore, to deeply reveal the functional effects of Zdhhc3 relying on palmitoylated Irhom2 in the setting of NASH pathogenesis in mice, we performed additional experiments using AAV‐TBG‐Irhom2 (mutation)‐mediated hepatocytes specific Irhom2 protein expression restoration in Irhom2/Zdhhc3‐HepDKO mice (Figure S12a, Supporting Information). The gene discussed is ZDHHC3; the disease is metabolic dysfunction-associated steatohepatitis.