Unsurprisingly, compared to mice with AAV‐TBG‐Irhom2 (WT)+AAV‐TBG‐Zdhhc3 restoration groups, gain‐of‐function of Irhom2 (C448A)+Zdhhc3 in mice failed to exert their acceleration over the course of HFHC‐induced NASH pathogenesis. Here, RHBDF2 is linked to metabolic dysfunction-associated steatohepatitis.