The serum contents of pro‐inflammatory cytokines (i.e., IL‐6, TNF‐α, IL‐1β, IL‐18, and CCL2), hepatic function indicators (i.e., ALT, AST, AKP, and GGT) (Figure 5l,m) and liver gene expression profile alterations associated with inflammation (Figure S7a, Supporting Information), fatty acid metabolism (Figure S7b, Supporting Information), and profibrotic genes (Figure S7c, Supporting Information) were markedly downregulated by Zdhhc3‐HepKO mice in the context of NASH. The gene discussed is IL18; the disease is metabolic dysfunction-associated steatohepatitis.