Of note, the pathogenesis of NASH is complicated, and is regarded as a heterogeneous disease, the pathogenesis of which is mediated by both external environmental factors and individual genetic determinants, which cannot be fully replicated in animal models.[28, 29] Thus we further studied ZDHHC3 function on a WTDF diet containing 15% w/v fructose‐drinking water‐mediated NASH model that as a complementary model simulates NASH pathogenesis. Here, ZDHHC3 is linked to metabolic dysfunction-associated steatohepatitis.