Furthermore, to deeply reveal the functional effects of Zdhhc3 relying on palmitoylated Irhom2 in the setting of NASH pathogenesis in mice, we performed additional experiments using AAV‐TBG‐Irhom2 (mutation)‐mediated hepatocytes specific Irhom2 protein expression restoration in Irhom2/Zdhhc3‐HepDKO mice (Figure S12a, Supporting Information). Here, RHBDF2 is linked to metabolic dysfunction-associated steatohepatitis.