Indeed, except for the mice injected with AAV‐TBG‐Zdhhc3, groups injected with AAV‐TBG‐Zdhhc3 (C157A), DHHC domain mutants, were not capable of promoting NASH diet‐triggered progression of steatohepatitis compared to those in corresponding controls, as evidenced by biochemical and immunohistochemistry analysis (Figure S14c–g, Supporting Information). The gene discussed is ZDHHC3; the disease is metabolic dysfunction-associated steatohepatitis.