RHBDF2 and metabolic dysfunction-associated steatohepatitis: Recently, IRHOM2, also called as RHBDF2, a key member of rhomboid family, acts as a critical initiator over the course of NASH by directly recruiting MAP3K7 signal to hyperactivate downstream MAP3K7‐JNK and NF‐κB p65 cascade pathways.[11, 12, 17] Excessive high‐energy diet intake did significantly upregulate IRHOM2 protein expression, and increased IRHOM2 also exhibits a positive correlation with NASH severity in human and rodents.