Importantly, all the NASH pathological symptoms that were alleviated by Zdhhc3 deficiency including elevated liver weight gain, glucose abnormality, liver lipid accumulation, increased liver pro‐inflammatory cytokines, proinflammation‐related gene expression profiles, liver collagen deposition, and hepatocellular injury were also significantly observed in Irhom2/Zdhhc3‐HepDKO mice (Figure 6a–j). This evidence concerns the gene RHBDF2 and metabolic dysfunction-associated steatohepatitis.