Genetic Sdh gene mutation is tumorigenesis, and also implicated in neurodegeneration and diabetes.[40, 41, 42] Tumor cells associated with Sdh mutations shut down the TCA cycle, but oxidize more glutamine or increase pyruvate carboxylase‐dependent pyruvate utilization to replenish TCA intermediates.[43, 44] Compared to the SDH‐deficient cells, adipocytes with Ifi27 deletion showed relatively minor metabolic remodeling possibly due to some remaining SDH activity. Here, SDHB is linked to diabetes mellitus.