To avoid aggregation or being insoluble, intramitochondrial molecular chaperones assist these nascent polypeptides folding or facilitate the degradation of misfolded or damaged proteins by proteases.[33] The chaperone TRAP1 modulates mitochondrial energy metabolism and redox homeostasis that shields cells from oxidative stress.[34, 35, 36] In cancer cells, deficiency of Trap1 results in decreased SDHB level, increased production of ROS and rewriting cellular metabolism,[20, 37] which is largely phenocopied by Ifi27 deletion in brown adipocytes. Here, SDHB is linked to cancer.