On the tumor cell membrane, the RKRKRKRK unit enhances the membrane affinity of the nano‐photosensitizer through electrostatic interactions, and the C16 unit inserts into the cell membrane to achieve prolonged cell membrane anchoring of the nano‐photosensitizer.[18] Under NIR photo‐irradiation, dual‐type photosensitizer YBS generated HO∙, ∙O2−, and 1O2 on the tumor cell membrane, effectively triggered immunogenic pyroptosis, increased intratumor CD8+ T cell infiltration and cytotoxic cytokine secretion, and initiated antitumor immunity. This evidence concerns the gene CD8A and neoplasm.