DIAPH1 and Hodgkins lymphoma: This mutation was first reported by Ueyama et al in two unrelated Japanese families suffering from HL in 2016.11 The DIAPH1 (NM_001079812.3):c.3610C > T (p.Arg1204Ter) mutation leads to early termination preceding the (RRKR1204-1207) amino acid motif in the DAD C-terminus and producing constitutively active DIA1 mutant which disrupts the autoinhibitory interaction of DID-DAD domains, and as a result of the continuous activity of the mutant protein, DFNA1 occurs.11