ACE and hydrops fetalis: HF guidelines recommend the use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (ACE-I/ARBs), beta-blockers, aldosterone antagonists, ivabradine, and, more recently, angiotensin receptor–neprilysin inhibitor (ARNI) at maximally tolerated target doses to reduce mortality and/ or rehospitalizations due to HF.