It is suggested that hsa_circ_0020397/miR‐138/PD-L1, TERT axis contributes to modulating cell viability, apoptosis, and invasion of CRC.23 As noted above, hsa_circ_0001445 and hsa_circ_0020397 could act as an oncogene or tumor suppressor gene in the various steps of carcinogenesis. This evidence concerns the gene CD274 and colorectal carcinoma.