Based on the multiple model, HLA-A*01 was significantly associated with the incidence of chronic GVHD and the patients with A*01 allele had 4.5-fold greater odds of extensive-type incidence of chronic GVHD [OR: 4.50; 90% CI: (1.74-11.64); P = 0.009]. The gene discussed is HLA-A; the disease is chronic graft versus host disease.