The most prevalent symptoms of the affected individuals who harbored KCNJ10 mutation were seizure (100%), DD (85.2%), ataxia (83.3%), sensorineural hearing loss (68.5%), abnormal blood ion concentration including hypokalemia, hypomagnesemia, hyponatremia, and hypochloremia (66.6%), gait disturbance (61.1%), urinary electrolyte imbalance (52.2%), involuntary movements (42.6%), speech disorder subsuming dysarthria and absent speech (42.5%), ID (35.2%), hyperreflexia (31.5%), proximal tubulopathy (29.6%), behavioral abnormality (27.7%), and pyramidal signs (20.7%) (Table S2.2). This evidence concerns the gene KCNJ10 and Hyperreflexia.