However, the contribution of potassium channelopathies to ID is not hitherto clear.8 SeSAME/EAST syndrome with autosomal-recessive inheritance pattern is a multi-systemic neuropsychiatric disease that emanates from compound heterozygous or homozygous mutations in KCNJ10, encoding Kir4.1, an ATP-sensitive inwardly rectifying potassium channel.25 Out of 54 patients with KCNJ10 mutation, 47 patients (87%) had missense, 5 (9.2%) had frame-shift, and 2 (3.7%) had a nonsense mutation (Table 3). The gene discussed is KCNJ10; the disease is EAST syndrome.