Hypertension (awareness, treatment, type of medication/herbal medication), Diabetes mellitus (awareness, treatment, type of medication/herbal medication/Insulin/Pen insulin), Hypercholesterolemia (awareness, treatment, type of medication/herbal medication), cardiovascular diseases (ischemic heart disease, angina pectoris, stroke, statin and aspirin use, interventional treatment), cancer, asthma and chronic obstructive pulmonary disease, menopause (females), dental pain, edentulism, oral health. This evidence concerns the gene INS and cardiovascular disorder.