PKD2 and autosomal dominant polycystic kidney disease: Mutations of the PKD1 and PKD2 genes affect about 85% and 15% of ADPKD cases, respectively.22 In concordance with other studies and the PKDB database, these rates were 74.2% (23 out of 31 detected variants) in PKD1 and 19.3% (6 out of 31 detected variants) in PKD2 in our study.