The secretion levels of MCP‐1, IL‐6, and IL‐8, which are biomarkers involved in promoting, activating, or accelerating the coagulation cascade and lesion formation in atherosclerosis, displayed a slight decreasing tendency in the unidirectional group compared with the bidirectional condition.[31, 32, 33] MCP‐1, IL‐6, and IL‐8, also exhibited significantly higher secretion levels in statically cultured blood vessels compared to bidirectional and unidirectional flow groups (Figure 3l–n). The gene discussed is CCL2; the disease is atherosclerosis.