There are several theories about the pathogenesis of local sarcoidosis-like reaction in the lung: Anti-PD-1 antibodies produce objective reactions in about 20% to 25% of patients with non-small cell lung cancer, melanoma or renal cancer.[8] However, the adverse events do not seem to hinder their curative effect. The gene discussed is PDCD1; the disease is non-small cell lung carcinoma.