AKT1 and malignant colon neoplasm: Initially identified as a tumor suppressor in breast and colon cancers, SASH1 has since been found to play a critical role in carcinogenesis.[12,13] Downregulation of SASH1 is associated with aggressive tumor progression, metastasis, and poor prognosis.[14,15] Additionally, the PI3K/Akt and TGF-β1 signaling pathways related to cell migration and invasion are consistent with SASH1’s differential expression.[16,17] These findings suggest that SASH1 may have multiple functions in various cell types.