In addition, it has been reported that CF can promote the production of NO in RAW 264.7 cells and reduce the proportion of neutrophils in the lung of mice.[12,13] PRA plays a powerful anti-inflammatory role by regulating the body’s immune process, reducing the development of rheumatoid arthritis, liver fibrosis, and asthma.[14–17] Combining previous studies, we speculate that PS, CF, and PRA play major roles in THSWD. Here, CFTR is linked to Hepatic fibrosis.