It is known that ALT is highly expressed in the liver, while AST is abundantly expressed in the kidney, muscle, and brain.[1] Fernando De Ritis, for the first time, has proposed the AST/ALT ratio (also named the De Ritis ratio) as a useful indicator for viral hepatitis.[2] Subsequently, this serological index was used to assess alcoholic and nonalcoholic liver disease, autoimmune liver diseases, hepatitis C, and hepatic fibrosis.[3–6]. This evidence concerns the gene GPT and hepatitis C virus infection.