Recently, in a large cohort of primary care patients in the UK (n = 29,316), the AST/ALT ratio was significantly associated with the increased risk of developing CVD in men over 10 years follow up.[19] Additionally, the predictive value of AST/ALT ratio for cardiovascular mortality has been found in a longitudinal cohort with 3494 Japanese community residents during 10-year follow-up.[20] Similarly, the prognostic value of high AST/ALT ratio has also been confirmed in Chinese patients with hypertension and peritoneal dialysis.[21–23]. The gene discussed is GPT; the disease is Hypertension.