Finally, RCN3, CASP4, SCAMP5, CHAC1, TRIB3, TNFRSF10B, DDX11, PDIA2, and PLA2G6 were kept as target genes, and their respective coefficients were calculated to construct an ERS-related genetic signature (ERSGRS) to predict ccRCC prognosis. This evidence concerns the gene CASP4 and nonpapillary renal cell carcinoma.