DSP and lethal acantholytic epidermolysis bullosa: In addition, mutations in the DSP gene result in a range of disorders from lethal acantholytic epidermolysis bullosa (LAEB) to striate palmar plantar keratoderma (SPPK) as well as arrhythmogenic cardiomyopathy (AC) and cardiocutaneous Carvajal syndrome7–13.