In our IL-1β mouse model of ESCC, similar to previous observations in this model as noted by Munch et al.27 in the context of BE induced GEJ adenocarcinoma, the esophageal cytokines/chemokine profile in the tissue microenvironment is altered towards a more proinflammatory state. The gene discussed is IL1B; the disease is gastroesophageal junction adenocarcinoma.