The IL-1β transgenic mouse model (ED-L2-IL-1β) was initially characterized by our group as a model of Barrett’s Esophagus (BE)-like metaplasia, glandular dysplasia and adenocarcinoma (12–18 M) affecting the squamo-columnar junction of the murine stomach26,27. The gene discussed is IL1B; the disease is esophageal adenocarcinoma.