As IL-1β is overexpressed in squamous cell carcinomas of the esophagus, oral cavity and nasal pharynx and its expression is linked to poor prognosis4,6,13,14,22,28,29, we sought to further characterize in detail the age-dependent progression of esophageal and tongue histopathological lesions in the transgenic IL-1β mice in different housing conditions and correlate with tissue inflammatory molecular expression profiles. Here, IL1B is linked to squamous cell carcinoma.