Interestingly, key factors known to induce immune evasion in tumor microenvironment, namely Foxp3 + (marker for T regulatory cells-Treg) (Supplemental Figs. S2, S5) and Il-17A (Fig. 5 and Supplemental Fig. S5) were significantly increased in the esophagus of IL-1β transgenic mice compared to wild type littermates. The gene discussed is IL1B; the disease is neoplasm.