EZH2 and small cell lung carcinoma: In SCLC cells, the mRNA level of Tpr was upregulated after SAHA treatment, but there was no significant change in the mRNA level of Tpr after a combined treatment of SAHA with EPZ-6438 compared with SAHA alone treatment (not shown), indicating that inhibition of EZH2 did not affect the increased expression of Tpr in SCLC cells treated with SAHA.