IRF3 and small cell lung carcinoma: As expected, western blotting analysis confirmed that the expression levels of p-IRF3, p-STING, and IL6 were reduced after co-treatment with SAHA and EPZ-6438 (Fig. 5C, D), indicating that it suppressed the secretion of SASP by inhibiting the cGAS-STING pathway in SCLC cells.