In particular, when C176, a specific inhibitor of STING, or cGAS inhibitor PF06928215 was used with SAHA, the expression level of IL6 protein as well as p-IRF3 and p-STING all decreased in SCLC cell lines, but the expression state of p21 protein, which reflects the senescent state, did not change with the secretion state of SASP (Figs. 2F, G and S2D, E). The gene discussed is IRF3; the disease is small cell lung carcinoma.