We also showed that after SAHA treatment, the proportion of CCF in SCLC cells with Tpr knockdown significantly decreased compared with the SAHA alone treatment group, the cGAS-STING signal pathway-associated protein p-IRF3 and p-STING, and SASP-associated protein IL6 were significantly down-regulated. The gene discussed is IRF3; the disease is small cell lung carcinoma.