The expression levels of IL6 and IL8 were remarkably repressed in SCLC cells that suppressed EZH2 transcription using interfering mRNA (Figs. 4C, D and S4F, G), suggesting that EZH2 is closely related to the secretion of SASP in SAHA-induced senescent SCLC cells. The gene discussed is CXCL8; the disease is small cell lung carcinoma.