As both CRHR1 and CRHR2 are expressed on the surface of mammalian ovaries and mediate CRH actions on ovulation and steroid biosynthesis [21], this repressed gene activation in the ovaries might impair the signaling essential for the female cycle regulation, steroid synthesis, follicles maturation, and ovulation phase, and contribute to the anovulatory cycles typical of PCOS. The gene discussed is CRH; the disease is polycystic ovary syndrome.