CRHR1 and Insulin resistance: As PCOS is associated with maladaptive stress-driven HPA activation [11] and HPA dysfunction plays a role in the metabolic and inflammatory pathogenesis of PCOS, including insulin resistance [27], and CRHR1 and CRHR2 are implicated in insulin secretion [22–26], CRHR1 and CRHR2 variants may predispose to the mental-metabolic risk for PCOS.