Consistently, depletion of BAP1 in MYCN-amplified BE2C and SH-EP Tet21/N cells but not MYCN non-amplified SH-EP Tet21/N+Dox cells, inhibited cell proliferation and migration in vitro (Fig. 2) and retarded tumor growth in subcutaneous and orthotopic xenograft mice models (Fig. 3 and Supplementary Fig. 3) in a MYCN-dependent manner. The gene discussed is BAP1; the disease is neoplasm.