MYCN and neuroblastoma: Currently, various strategies developed to block MYCN include: (1) inhibiting MYCN expression by blocking MYCN transcription regulators (e.g., epigenetic reader proteins, such as BET protein BRD4), (2) targeting upstream regulators regulating MYCN protein stability, (3) promoting NB cell apoptosis via activating p53 pathway, and (4) inducing cell differentiation [5].