BAP1 and neoplasm: Although the MYCN protein was elevated upon BAP1 overexpression, our results of in vitro cells assay and in vivo xenograft assay using the BAP1 overexpressed BE2C and/or SH-EP Tet21/N cells demonstrated that, BAP1 overexpression could also inhibit cell proliferation, migration, colony formation and tumor growth which is similar with the results of BAP1 knockdown.