However, although the MYCN-mediated inhibitory effect of BAP1 deficiency on the growth of MYCN-amplified NB cells was significant and solid which is confirmed by biochemistry assays (Fig. 1), in vitro cellular biological assays (Fig. 2) and in vivo mice xenograft assays (Fig. 3), the results generated from the BAP1 overexpression BE2C cells are unappreciated. This evidence concerns the gene BAP1 and neuroblastoma.