Although the MYCN protein was elevated upon BAP1 overexpression, our results of in vitro cells assay and in vivo xenograft assay using the BAP1 overexpressed BE2C and/or SH-EP Tet21/N cells demonstrated that, BAP1 overexpression could also inhibit cell proliferation, migration, colony formation and tumor growth which is similar with the results of BAP1 knockdown. Here, MYCN is linked to neoplasm.