Similarly, pathway analysis of significantly upregulated genes in pooled pseudobulk samples comparing combination-treated mice to control (Supplementary Fig. 6A (right) and Supplementary Data 6 and  7) revealed a striking positive enrichment of multiple interferon-inducible inflammatory signaling (Cxcl9, Cxcl10, Il15, Il15ra, Tnf) and antigen presentation pathways (H2-Ab1, Tap1, Cd74) in the tumor, myeloid and fibroblast compartments (Fig. 5d). This evidence concerns the gene TNF and neoplasm.