TGFB1 and neoplasm: On the other hand, tumor-derived Exos may have immunosuppressive molecules on their surfaces, such as (membrane-associated) TGF-β1 [101] or FasL, which may cause DC differentiation inhibition from myeloid precursors, inhibition of NK cell cytotoxic activity, inhibition of T lymphocytes and promotion of Treg expansion that leads to immune system evasion or induces an antiproliferative effect [102].