The most common all-grade TRAEs (frequency of ≥ 15%) were hypertriglyceridemia (65%), hypertension (57%), hypercholesterolemia (52%), proteinuria (50%), diarrhea (50%), hand-foot syndrome (35%), hypothyroidism (33%), elevated thyroid stimulating hormone (28%), rash (27%), elevated alanine transaminase (25%), elevated low-density lipoprotein (22%), elevated aspartate aminotransferase (20%), fecal occult blood (17%), bleeding gums (17%), oral mucositis (15%), urine occult blood (15%), and hematuria (15%). The gene discussed is GPT; the disease is familial hypercholesterolemia.