The morphological neoplastic tissue compartment (Fig. 4a) included: apoptosis related (CASP3, BIK), proliferation related (CCND1, PCNA, MYBL2), tumour associated stromal genes (TIMP1, CXCL1, COL1A2, S100A4, CD44), energy metabolism markers (LDHA, PKM), oxidative stress (SOD1, GPX1, PRDX2), stemness- (CD44), angiogenesis- (MET) associated genes, and Oncotype DX genes (INHBA, MYBL2). Here, TIMP1 is linked to neoplasm.