To the best of our knowledge, this is the first study to demonstrate that EpCAM/EpEX binds to HGFR and induces tumor progression and metastasis through ERK and FAK-AKT by inducing HGFR activation and GSK3β-Snail and β-catenin signaling in colon cancer cells. Here, SNAI1 is linked to malignant colon neoplasm.