We also highlight context-specific regulatory effects for genes involved in metabolic (e.g. obesity, NTRK2, [35]) and neurological (e.g. schizophrenia, MAN2A1, [52]) diseases, and for genes with a role in biological processes such as adipogenesis (e.g. DEPTOR, [53]). Here, DEPTOR is linked to obesity due to melanocortin 4 receptor deficiency.