A recent study showed that KLF5 collaborated with FOXO1 to regulate atrophy-related processes, including metabolic changes and E3-ubiquitin ligase–mediated proteolysis, and KLF5 expression increased significantly with age and sarcopenia and was positively correlated with the expression of the atrophy-related ubiquitin ligase genes FBXO32 and TRIM63 (36). This evidence concerns the gene FOXO1 and sarcopenia.