TPH2 and Anxiety: Previously, behavioral and molecular findings of lower propensity to despair behavior, anxiety and other signs of maladaptive stress response demonstrated in Tph2+/− mice (Gorlova et al. 2020; Strekalova et al. 2021a, b; Svirin et al. 2022a) and in Tph2−/− mice (Savelieva et al. 2008; Weidner et al. 2019) have been demonstrated.